Protein Details: Neuronal acetylcholine receptor subunit alpha-7

Protein ID

ICDB_Pro_0607

Protein Name

Neuronal acetylcholine receptor subunit alpha-7

Gene Name

CHRNA7

Organism

Bos taurus (Bovine)

Length

499 amino acids

AlphaFoldDB

AF-P54131-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions. .

Sequence

MRGSLCLALAASILHVSLQGEFQRKLYKDLVKNYNPLERPVANDSLPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMTWTDHYLQWNASEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGVLGKRSEKFYECCKEPYPDVTFTVSIRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVVLLNWCAWFLRMKRPGEDKVRPACQHNERRCSLASVEMSAVAGPPATNGNLLYIGFRGLDTMHCAPTPDSGVVCGRVACSPTHDEHLLHAGQPSEGDPDLAKILEEVRYIAHRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTILCTIGILMSAPNFVEAVSKDFA

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1016/0378-1119(94)00914-e; 10.1006/geno.1996.0119; 10.1007/bf02736842; 10.1016/s0014-5793(96)01383-x; 10.1038/414865a; 10.1101/gr.2596504; 10.1124/mol.105.017459; 10.1111/jnc.13718; 10.1016/j.bbamem.2012.02.008; 10.1038/ng1095-201; 10.1212/wnl.53.8.1749; 10.1001/archneur.60.11.1625

RefSeq

NP_000735.1 [P43681-1]; NP_001243502.1; XP_011526826.1